Buy cheap Flagyl

Flagyl (Metronidazole) is a nitroimidazole anti-infective drug used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. It is marketed by Pfizer under the trade name Flagyl in the US, while Sanofi-Aventis markets Flagyl (Metronidazole) globally under the same tradename, Flagyl, and also by various generic manufacturers, who sell it at a cheaper price. Flagyl (Metronidazole) is also used as a gel preparation in the treatment of the dermatological conditions such as rosacea (Rozex and MetroGel by Galderma) and fungating tumours (Anabact, Cambridge Healthcare Supplies).

Flagyl (Metronidazole) is a prodrug. It is converted in anaerobic organisms by the redox enzyme pyruvate-ferredoxin oxidoreductase. The nitro group of Flagyl (Metronidazole) is chemically reduced by ferredoxin (or a ferredoxin-linked metabolic process) and the products are responsible for disrupting the DNA helical structure, thus inhibiting nucleic acid synthesis.

Flagyl (Metronidazole) is selectively taken up by anaerobic bacteria and sensitive protozoal organisms because of the ability of these organisms to reduce Flagyl (Metronidazole) to its active form intracellularly.

Systemic Flagyl (Metronidazole) is indicated for the treatment of:

- Vaginitis due to Trichomonas vaginalis (protozoal) infection in both symptomatic patients as well as their asymptomatic sexual contacts; and due to bacterial Gardnerella or Mycoplasma hominis infection in symptomatic patients
- Pelvic inflammatory disease in conjunction with other antibiotics such as ofloxacin, levofloxacin, or ceftriaxone
- Protozoal infections due to Entamoeba histolytica (Amoebic dysentery or Hepatic abscesses), and Giardia lamblia (Giardiasis) should be treated alone or in conjunction with iodoquinol or diloxanide furoate
- Anaerobic bacterial infections such as Bacteroides fragilis, spp, Fusobacterium spp, Clostridium spp, Peptostreptococcus spp, Prevotella spp, or any other anaerobes in intraabdominal abscess, peritonitis, empyema, pneumonia, aspiration pneumonia, lung abscess, diabetic foot ulcer, meningitis and brain abscess, bone and joint infections, septicemia, endometritis, tubo-ovarian abscess, or endocarditis
- Pseudomembranous colitis due to Clostridium difficile
- Helicobacter pylori eradication therapy, as part of a multi-drug regimen in peptic ulcer disease
- Prophylaxis for those undergoing potentially contaminated colorectal surgery and may be combined with neomycin
- Acute gingivitis and other dental infections (TGA approved, non-Food and Drug Administration (FDA) approved)
- Crohn's disease with colonic or perianal involvement (non-FDA approved)

Topical Flagyl (Metronidazole) is indicated for the treatment of rosacea, and in the treatment of malodorous fungating wounds.
Common adverse drug reactions (?1% of patients) associated with systemic Flagyl (Metronidazole) therapy include: nausea, diarrhea, and/or metallic taste in the mouth. Intravenous administration is commonly associated with thrombophlebitis. Infrequent adverse effects include: hypersensitivity reactions (rash, itch, flushing, fever), headache, dizziness, vomiting, glossitis, stomatitis, dark urine, and/or paraesthesia.

High doses and/or long-term systemic treatment with Flagyl (Metronidazole) is associated with the development of black hairy tongue, leukopenia, neutropenia, increased risk of peripheral neuropathy and/or CNS toxicity.

Flagyl (Metronidazole) is listed by the International Agency for Research on Cancer (IARC) as a potential human carcinogen. Although some of the testing methods have been questioned, it has been shown to cause cancer in experimental animals. Nevertheless, it appears to have a fairly low potential for cancer risk and under most circumstances the benefits of treatment outweighs the risk.

Common adverse drug reactions associated with topical Flagyl (Metronidazole) therapy include local redness, dryness, and/or skin irritation; and eye watering (if applied near eyes).

Interaction with alcohol

Consuming ethanol (alcohol) while using Flagyl (Metronidazole) causes a disulfiram-like reaction with effects that can include nausea, vomiting, flushing of the skin, tachycardia (accelerated heart rate), shortness of breath, and even death. Consumption of alcohol should be avoided by patients during systemic Flagyl (Metronidazole) therapy and for at least 24 hours after completion of treatment. However, the occurrence of this reaction in the clinical setting has recently been questioned by some authors, and a possible central toxic seratonin reaction for the alcohol intolerance suggested.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.